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Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.
Santa Cruz Biotechnology
fumarate hydratase (J-13) | Santa Cruz Biotechnology
mouse monoclonal IgG2b; fumarate hydratase Antibody (J-13) is an IgG2b κ mouse monoclonal fumarate hydratase antibody that detects precursor mitochondrial and cytoplasmic mature chains of fumarate hydratase of human origin by WB, IP, IF, IHC(P) and ELISA. fumarate hydratase Antibody (J-13) is available as the non-conjugated anti-fumarate hydratase antibody form. Fumarate hydratase, a ubiquitously expressed mitochondrial enzyme, catalyses the reversible hydration of fumaric acid to yield l-malic acid during the Krebs cycle. Germline mutations in the fumarate hydratase gene cause a predisposition to renal defects such as multiple cutaneous and uterine leiomyoma (MCL) syndrome. Furthermore, mutations also correlate with renal and smooth muscle tumors, but not with prostate cancer. Additionally, like other metabolic diseases, fumarate hydratase deficiency correlates with seizures, due to prenatal brain dysgenesis.
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