mouse monoclonal IgG3; Ganglioside GD2 Antibody (11H3) is an IgG3 mouse monoclonal Ganglioside GD2 antibody that detects Ganglioside GD2 of human origin by WB and ELISA. Ganglioside GD2 Antibody (11H3) is available as the non-conjugated anti-Ganglioside GD2 antibody form. Gangliosides are key players in determining the nature of tetraspanin interactions and are major components of the tetraspanin web. The GD2 gangliosides are sialic acid-containing glycosphingolipids that play a role in signal transduction and cell-cell recognition. Ganglioside GD2 production is controlled by GM2/GD2 Synthase. It is found in all tissues and localizes to the cell surface. Ganglioside GD2 is involved in the onset of apoptosis by dephos-phorylating focal adhesion kinases. Ganglioside GD2 is abundant on neuroblastoma cells and on all tumors originating in the neuroectoderm, such as malignant melanoma, adult T cell leukemia, and certain colon and gastric cancers. This suggests that Ganglioside GD2 may be a good target for immu-notherapy. Additionally, Ganglioside GD2 is found on mesenchymal stromal cells and may be a unique surface marker.