mouse monoclonal IgG1; Sam 68 Antibody (7-1) is an IgG1 κ mouse monoclonal Sam 68 antibody (also designated KHDR1 antibody, KH RNA Binding Domain Containing antibody, Signal Transduction Associated 1 antibody, Src-Associated In Mitosis 68 KDa Protein antibody, KH Domain-Containing RNA-Binding Signal Transduction-Associated Protein 1 antibody, P21 Ras GTPase-Activating Protein-Associated P62 antibody, GAP-Associated Tyrosine Phosphoprotein P62 antibody, P62 antibody, KH Domain Containing RNA Binding Signal Transduction Associated 1 antibody, or GAP-Associated Tyrosine Phosphoprotein P62 (Sam68) antibody) that detects the Sam 68 protein of mouse, rat and human origin by WB, IP, IF and IHC(P). Sam 68 Antibody (7-1) is available as both the non-conjugated anti-Sam 68 antibody form, as well as multiple conjugated forms of anti-Sam 68 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Sam 68 is a protein that is phosphorylated on tyrosine and functions as a substrate for Src family tyrosine kinases during mitosis. Sam 68 also associates with several SH2 and SH3 domain-containing signaling proteins, such as GRB2 and PLC γ1. Originally cloned as Ras GAP-associated p62, further investigations have shown that Sam 68 and Ras GAP-associated p62 are not antigenically related, nor are they encoded by the same gene. Like Sam 68, the Sam 68-like mammalian proteins, SLM-1 and SLM-2, demonstrate RNA binding activity. Also like Sam 68, SLM-1 is tyrosine phosphorylated and functions as an adapter protein for signaling molecules, including GRB2, PLC γ1, Fyn and Ras GAP. SLM-2 is not tyrosine phosphorylated, nor does it appear to associate with GRB2, PLC γ1, Fyn or Ras GAP, indicating that SLM-2 may not be an adapter protein for these proteins.