mouse monoclonal IgG2b; MDR1/ABCB1 Antibody (G-1) is an IgG2b κ mouse monoclonal MDR1 antibody that detects MDR1 of human origin by WB, IP, IF, IHC(P) and ELISA. MDR1/ABCB1 Antibody (G-1) is available as the non-conjugated anti-MDR1 antibody form, as well as multiple conjugated forms of anti-MDR1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cells selected for resistance to a single cytotoxic drug may become cross-resistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. MDR1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The MDR1 gene is also known as ABCB1 and is located on human chromosome 7. The mouse homolog of MDR1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.