mouse monoclonal IgG2a; DUSP22 Antibody (9J2) is an IgG2a κ mouse monoclonal DUSP22 antibody (also designated MKPX antibody) that detects the DUSP22 protein of human origin by WB, IP and ELISA. DUSP22 Antibody (9J2) is available as the non-conjugated anti-DUSP22 antibody. Mitogen-activated protein (MAP) kinases are a large class of proteins involved in signal transduction pathways that are activated by a range of stimuli and mediate a number of physiological and pathological changes in the cell. Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. DUSP22 dephosphorylates ERK2 MAP kinase and JNK. DUSP22 displays highest in thymus, but it is also detectable in monocytes and lymphocytes.