mouse monoclonal IgG2b; CYP2J2 Antibody (D-6) is an IgG2b κ mouse monoclonal CYP2J2 antibody (also designated CYP2J2 antibody) that detects the CYP2J2 protein of human origin by WB, IP, IF and ELISA. CYP2J2 Antibody (D-6) is available as both the non-conjugated anti-CYP2J2 antibody form, as well as multiple conjugated forms of anti-CYP2J2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2J2 (cytochrome P450 2J2), also known as CPJ2, is a member of the cytochrome P450 protein superfamily. Localized to the ER (endoplasmic reticulum) and microsomal membranes, CYP2J2 is one of three cytochrome P450 enzymes that are responsible for metabolizing arachidonic acid to epoxyeicosatrienoic acids. Functioning via an NADPH-dependent olefin epoxidation, CYP2J2 epoxidizes endogenous cardiac arachidonic acid pools to four different isoforms of epoxyeicosatrienoic acid, all of which are important regulators of cardiovascular homeostasis and vascular tone. CYP2J2 is highly expressed in the heart with low levels of expression found in the liver, colon and kidneys. Up-regulation of CYP2J2 by a c-Jun responsive pathway is thought to promote the neoplastic phenotype of certain carcinoma cells, implicating CYP2J2 in carcinogenesis.