mouse monoclonal IgG1; nardilysin Antibody (A-6) is an IgG1 κ mouse monoclonal nardilysin antibody (also designated nardilysin antibody) that detects the nardilysin protein of mouse, rat and human origin by WB, IP, IF and ELISA. nardilysin Antibody (A-6) is available as both the non-conjugated anti-nardilysin antibody form, as well as multiple conjugated forms of anti-nardilysin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Aspartyl, serine, thiol and metalloenzyme proteases can be endoproteases, which activate protein precursors by cleavage at basic residues. Human nardilysin, also designated N-arginine dibasic convertase, NRD1 or NRD convertase, is a 1,147 amino acid metalloendopeptidase that cleaves propeptide and proprotein substrates at the amino-terminus of arginine residues in dibasic moieties. The nardilysin gene maps to chromosome 1p32.2 and is expressed as a 3.6-kb transcript primarily in adult heart, skeletal muscle and testis. In the testis, nardilysin appears to be restricted to germ cells. As a member of the insulinase family, nardilysin is a specific receptor for heparin-binding epidermal growth factor-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration via ErbB1. Nardilysin exhibits a significant degree of similarity to insulinase and to two yeast processing enzymes, Axl1 and Ste2. Defects in the gene encoding nardilysin are linked to inherited neuromuscular disorders.