mouse monoclonal IgG2a; N-Myc Antibody (2) is an IgG2a mouse monoclonal N-Myc antibody (also designated N-Myc antibody or MYCN antibody) that detects N-Myc p67 of mouse, rat and human origin by WB, IP and IF. N-Myc Antibody (2) is available as the non-conjugated anti-N-Myc antibody form, as well as multiple conjugated forms of anti-N-Myc antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines (3,5). The extent of N-Myc amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein designated Max.