mouse monoclonal IgG2a; SV40 T Ag Antibody (Pab 101) is an IgG2a κ mouse monoclonal SV40 T Ag antibody (also designated SV40 T Ag antibody or SV40 T Antigen antibody) that detects the C-terminus of large T antigen of SV40 origin by WB, IP, IF and IHC(P). SV40 T Ag Antibody (Pab 101) is available as the non-conjugated anti-SV40 T Ag antibody form, as well as multiple conjugated forms of anti-SV40 T Ag antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Simian virus SV40 has provided an important model for studies of cellular mechanisms involved in a malignant transformation. The major SV40 translational products include the large T antigen and the small T antigen, both of which are encoded by the early region of the SV40 viral ge-nome. The large T antigen complexes with the p53 suppressor gene, resulting in its functional inactivation, thus promoting cell transformation. In addition, SV40 large T antigen binds DNA polymerase and the transcription factor AP-2. It also forms complexes with a second tumor supressor gene-encoded protein, Rb 105. Binding of SV40 T antigen is specific for the "pocket" domain of Rb p105, which is also the binding site for the E2F cellular transcription factor.