mouse monoclonal IgG1; NFKBIA/IkB alpha Antibody (H-4) is an IgG1 κ mouse monoclonal IkB alpha antibody (also designated NFKBIA antibody, Ikappab alpha antibody or IκBα antibody) that detects IkB alpha of mouse, rat and human origin by WB, IP, IF, IHC(P), FCM and ELISA. IκB-α Antibody (H-4) is available as the non-conjugated anti-IκB-α antibody form, as well as multiple conjugated forms of anti-IκB-α antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. On the basis of both functional and structural considerations, members of the IκB family of proteins can be divided into four groups. The first of these groups, IκB-α, includes the avian protein pp40 and the mammalian MAD-3, both of which inhibit binding of p50–p65 NFκB complex or Rel protein to their cognate binding sites but do not inhibit the binding of p50 homodimer to κB sites, suggesting that the IκB-α family binds to the p65 subunit of p50-p65 heterocomplex through ankyrin repeats. The second member of the IκB family is represented by a protein designated IκB-β. The third group of IκB proteins is represented by IκB-γ, a protein identical in sequence with the C-terminal domain of the p110 precursor of NFκB p50 and expressed predominantly in lymphoid cells. An additional IκB family member has been identified as IκB-e, a protein which has several phosphorylated forms and is primarily found complexed with Rel A and/or c-Rel.