mouse monoclonal IgG1; La/SSB Antibody (B-8) is an IgG1 κ mouse monoclonal La/SSB antibody that detects La/SSB of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. La/SSB Antibody (B-8) is available as the non-conjugated anti-La/SSB antibody form, as well as multiple conjugated forms of anti-La/SSB antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Ro autoantigens are of clinical significance because antibodies directed against them are found in most patients with primary Sjogren syndrome, subacute cutaneous lupus erythematosus (SLE), neonatal lupus erythematosus, ANA-negative lupus erythematosus, and systemic lupus erythematosus-like disease secondary to homozygous C2 or C4 complement deficiency. Ro/SSA is a ribonucleoprotein that binds to autoantibodies in 35 to 50% of patients with SLE and in up to 97% of patients with Sjogren syndrome. The Ro/SSA particle consists of a single immunoreactive protein noncovalently bound with one of four small RNA molecules. Most anti-Ro/SSA-positive sera have antibodies not only against the immunoreactive protein, but also against an Ro/SSA protein. The genes which encode the two proteins map to human chromosomes 11p15.5 and 1q31, respectively. La/SSB is an autoimmune RNA-binding protein that plays a role in the transcription of RNA polymerase III was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and SLE.