mouse monoclonal IgG2a; ZCSL3 Antibody (E-3) is an IgG2a κ mouse monoclonal ZCSL3 antibody (also designated ZCSL3 antibody) that detects the ZCSL3 protein of human origin by WB, IP, IF and ELISA. ZCSL3 Antibody (E-3) is available as both the non-conjugated anti-ZCSL3 antibody form, as well as multiple conjugated forms of anti-ZCSL3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The CSL-type zinc finger-containing proteins (ZCSLs) are homologs of the S. cerevisiae diphthamide methyltransferase proteins (DPHs). These enzymes are involved in the synthesis of diphthamide, a protein found on translation elongation factor EF-2 that is the target of bacterial ADP-ribosylating toxins. ZCSL1, ZCSL2 and ZCSL3 (CSL-type zinc finger-containing protein 1, 2 and 3, respectively) are members of the ZCSL family of proteins and each contain one DPH-type zinc finger. ZCSL2, also known as DPH3 or DESR1, is highly expressed in spleen, heart, lung, liver and thymus and is essential in the first step of dipthamide synthesis. Down-regulation of ZCSL2 increases the release of proteoglycans, suggesting a possible role in protein secretion. ZCSL1 and ZCSL3, also known as DPH3B and DPH4, respectively, are additional members of the ZCSL family of dipthamide-synthesizing enzymes.