mouse monoclonal IgG2a; PIKE Antibody (G-9) is an IgG2a κ mouse monoclonal PIKE antibody (also designated PIKE antibody) that detects the PIKE protein of mouse, rat and human origin by WB, IP, IF and ELISA. PIKE Antibody (G-9) is available as both the non-conjugated anti-PIKE antibody form, as well as multiple conjugated forms of anti-PIKE antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. PIKE (Phosphatidylinositol-3-kinase enhancer), also known as CENTG1 (Centaurin-gamma-1), AGAP2 or GGAP2, is a 1,192 amino acid protein that is expressed as two isoforms, namely PIKE-L, which is brain-specific, and PIKE-A (also known as PIKE-S), which is found throughout the body. Localized to both the nucleus and the cytoplasm, PIKE functions as a GAP (GTPase-activating protein) that is activated by phosphatidylinositol 4,5-bisphosphate (PIP2) and plays an important role in the prevention of neuronal apoptosis. Specifically, PIKE interacts with proteins such as ARF1, ARF5, PLC γ1 and Homer and, via these interactions, regulates endosomal trafficking and protein coupling events. PIKE contains one PH domain, one Miro domain, one Arf-GAP domain and two ANK repeats through which it conveys its protein-binding and GAP activity. While overexpression of PIKE causes tumor growth and invasion, reduced levels of PIKE are associated with neuronal cell death.