mouse monoclonal IgG2b; HRPAP20 Antibody (G-10) is an IgG2b κ mouse monoclonal HRPAP20 antibody (also designated HRPAP20 antibody) that detects the HRPAP20 protein of human origin by WB, IP, IF and ELISA. HRPAP20 Antibody (G-10) is available as both the non-conjugated anti-HRPAP20 antibody form, as well as multiple conjugated forms of anti-HRPAP20 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. HRPAP20 (hormone-regulated proliferation-associated protein 20) is a 175 amino acid protein encoded by the human gene NDUFAF4. HRPAP20 is a novel hormone-regulated, proliferation-associated protein. In tumor cell lines, constitutive HRPAP20 expression enhanced proliferation and suppressed apoptosis, characteristics frequently associated with malignant progression. Invasive breast cancer cell lines and human breast tumor specimens express elevated HRPAP20, which can increase malignant cell invasion in transfection experiments using such cell lines as MCF-7 and MDA-MB-231. Transfection with HRPAP20 will increase secretion of matrix metalloproteinase-9 (MMP-9). Conversely, knockdown of HRPAP20 with small interfering RNA will reduce invasion and inhibit secretion of MMP-9.