mouse monoclonal IgG2b; Axotrophin Antibody (B-2) is an IgG2b κ mouse monoclonal Axotrophin antibody (also designated Axotrophin antibody) that detects the Axotrophin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Axotrophin Antibody (B-2) is available as both the non-conjugated anti-Axotrophin antibody form, as well as multiple conjugated forms of anti-Axotrophin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Axotrophin is a stem cell gene that encodes a protein which is involved in T lymphocyte regulation (especially in regulating the proliferation) and leukemia inhibitory factor (LIF) release. LIF is a neuropoietic cytokine that is important for stem cell regulation and thymocyte stimulation. Both Axotrophin and LIF are linked to transplantation intolerance. Axotrophin is also involved in corpus callosum differentiation and may play a role in glial cell line-derived neurotrophic factor (GDNF)-dependent sensory neuron survival in the substantia gelatinosa of the adult spinal cord. Axotrophin is primarily expressed in the hippocampus, cortex, purkinje and granule cells of the cerebellum.