mouse monoclonal IgG2b; PP2B-Aα Antibody (D-9) is an IgG2b κ mouse monoclonal PP2B-A alpha antibody (also designated PP2BA antibody, Protein Phosphatase 3 Catalytic Subunit Alpha antibody, Serine/Threonine-Protein Phosphatase 2B Catalytic Subunit Alpha Isoform antibody, Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform antibody, CAM-PRP Catalytic Subunit antibody, Calcineurin A Alpha antibody, CALNA antibody, PPP2B antibody, CNA1 antibody, Protein Phosphatase 3 Catalytic Subunit Alpha Isozyme antibody, or CALNA1 antibody) that detects the PP2B-A alpha protein of mouse, rat and human origin by WB, IP, IF and ELISA. PP2B-Aα Antibody (D-9) is available as both the non-conjugated anti-PP2B-A alpha antibody form, as well as multiple conjugated forms of anti-PP2B-A alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit and a catalytic subunit. Four major families of protein phosphatase catalytic subunit have been identified, designated PP1, PP2A, PP2B and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4), is a putative member of a novel PP family. The PP2B family comprises subfamily members PP2B-Aα, PP2B-Aβ and PP2B-Aγ. Two additional regulatory subunits been identified, designated PP2B-B1 and PP2B-B2.