mouse monoclonal IgG1; Homer Antibody (D-3) is an IgG1 κ mouse monoclonal Homer antibody (also designated HOMER1 antibody, or SYN47 antibody) that detects the Homer protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Homer Antibody (D-3) is available as both the non-conjugated anti-Homer antibody form, as well as multiple conjugated forms of anti-Homer antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Homer family proteins, also designated Vesl (for VASP/Ena-related gene upregulated during seizure) and LTP, are immediate early gene products that bind to group 1 metabotropic glutamate receptors (mGluRs), proteins involved in triggering intracellular calcium release. Unlike Homer-1a, the prototype member of the Homer family, other Homer family members (Homer-1b and -1c, Homer-2a, -2b and -2c and Homer-3) are constitutively expressed and contain a coiled-coil (CC) domain that mediates self-multimerization. Homer-1a is enriched at excitatory synapses, does not multimerize and appears to block the association of mGluRs to CC-Homer proteins. Homer proteins have also been shown to link mGluRs with the inositol triphosphate receptors (IP3R).