mouse monoclonal IgG1; cyclin D1 Antibody (HD11) is an IgG1 mouse monoclonal cyclin D1 antibody that detects cyclin D1 of mouse, rat and human origin by WB, IP, IF and IHC(P). cyclin D1 Antibody (HD11) is available as the non-conjugated anti-cyclin D1 antibody form, as well as multiple conjugated forms of anti-cyclin D1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The proliferation of eukaryotic cells is controlled at specific points in the cell cycle, particularly at the G1 to S and the G2 to M transitions. It is well established that the Cdc2 p34-cyclin B protein kinase plays a critical role in the G2 to M transition while cyclin A associates with Cdk2 p33 and functions in S phase. Considerable effort directed towards the identification of G1 cyclins has led to the isolation of cyclin D, cyclin C and cyclin E. Of these, cyclin D corresponds to a putative human oncogene, designated PRAD1, which maps at the site of the Bcl1 rearrangement in certain lymphomas and leukemias. Two additional human type D cyclins, as well as their mouse homologs, have been identified. Evidence has established that members of the cyclin D family function to regulate phosphorylation of the retinoblastoma gene product, thereby activating E2F transcription factors.