mouse monoclonal IgG1; UCH-L5 Antibody (C-4) is an IgG1 κ mouse monoclonal UCH-L5 antibody (also designated UCH-L5 antibody) that detects the UCH-L5 protein of mouse, rat and human origin by WB, IP, IF and ELISA. UCH-L5 Antibody (C-4) is available as both the non-conjugated anti-UCH-L5 antibody form, as well as multiple conjugated forms of anti-UCH-L5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. As a component of the 19S regulatory complex of the 26S proteosome, UCH-L5 (ubiquitin carboxyl-terminal hydrolase isozyme L5), also known as UCH37, is a 329 amino acid protein that functions to edit polyubiquinated protein substrates. Since UCH-L5 has the potential to rescue ubiquinated proteins, including oncogenic proteins, from proteasomal degradation, it is likely that deregulation of UCH-L5 may affect tumor growth. Through associations with Smad7, UHC-L5 can dramatically upregulate TGFβ-dependent gene expression by de-ubiquinating and stabilizing TGFβ RI. Also, since overexpression of UCH-L5 and other deubiquitinating enzymes has been observed in many cancer cell lines, inhibition of these proteins may be of some interest in designing therapies for cancer treatment. There are four isoforms of UCH-L5 that exist as a result of alternative splicing events.