mouse monoclonal IgG2a; Calcyon Antibody (G-8) is an IgG2a κ mouse monoclonal Calcyon antibody (also designated Calcyon antibody) that detects the Calcyon protein of mouse, rat and human origin by WB, IP, IF and ELISA. Calcyon Antibody (G-8) is available as both the non-conjugated anti-Calcyon antibody form, as well as multiple conjugated forms of anti-Calcyon antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Calcyon is a single transmembrane protein that interacts with D1 dopamine receptors. Dopamine is a neurotransmitter that regulates synaptic transmission involved in learning and memory. D1 receptors, the most abundant dopamine receptor in the central nervous system, appear to modulate the activity of D2 dopamine receptors, mediate various behavioural responses, and regulate neuron growth and differentiation. Calcyon is present in neuronal cell bodies and processes of the cortex and hippocampus, and it is especially abundant in pyramidal neurons. Interaction of Calcyon with D1 receptors results in a release of intracellular calcium.