mouse monoclonal IgG2b; PKA Iα/β reg Antibody (B-6) is an IgG2b κ mouse monoclonal PKA I alpha / beta reg antibody (also designated PKA Iα/β reg antibody) that detects the PKA I alpha / beta reg protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. PKA Iα/β reg Antibody (B-6) is available as both the non-conjugated anti-PKA I alpha / beta reg antibody form, as well as multiple conjugated forms of anti-PKA I alpha / beta reg antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The second messenger cyclic AMP (cAMP) mediates diverse cellular responses to external signals such as proliferation, ion transport, regulation of metabolism and gene transcription by activation of the cAMP-dependent protein kinase (cAPK or PKA). Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme, resulting in release of active catalytic subunits. Four different PKA regulatory subunits have been identified, designated Iα, Iβ, IIα and IIβ. The PKA Iα reg protein is a tissue-specific extinguisher that downregulates the expression of seven liver genes in heptoma x fibroblast hybrids. Functional null mutations in the gene that codes for PKA Iα reg cause Carney complex (CNC). CNC is an autosomal dominant multiple neoplasia syndrome. CNC is associated with a variety of characterized symptoms such as cardiac and other myxomas, spotty skin pigmentation, endocrine tumors and psammamatous melanotic schwannomas.