mouse monoclonal IgG1; CLCA1 Antibody (E-4) is an IgG1 κ mouse monoclonal CLCA1 antibody (also designated CLCA1 antibody) that detects the CLCA1 protein of mouse, rat and human origin by WB, IP, IF and ELISA. CLCA1 Antibody (E-4) is available as both the non-conjugated anti-CLCA1 antibody form, as well as multiple conjugated forms of anti-CLCA1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The calcium-activated chloride channel (CLCA) protein family, which includes the human homologs CLCA1 and CLCA2, display distinct tissue distribution patterns. CLCA1 is expressed as a precursor protein that is processed into two cell surface associated subunits and a group of proteins. CLCA1 is upregulated by interleukin-9 and regulates the expression of mucins. CLCA1 may provide a therapeutic target to control mucus overproduction in airway disease patients with cystic fibrosis. CLCA2 expression is downregulated in breast cancer and therefore, is thought to act as a tumor suppressor in normal cells. CLCA3 is a structurally divergent member of the CLCA family that does not function as a channel protein. CLCA4 is a CLCA member that is expressed in human rectal mucosa, CLCA5 shows strong expression in eye and spleen, and CLCA6 is primarily expressed in intestine and stomach.