mouse monoclonal IgG1; CD-MPR Antibody (H-7) is an IgG1 κ mouse monoclonal CD-MPR antibody (also designated CD-MPR antibody) that detects the CD-MPR protein of mouse, rat and human origin by WB, IP, IF and ELISA. CD-MPR Antibody (H-7) is available as both the non-conjugated anti-CD-MPR antibody form, as well as multiple conjugated forms of anti-CD-MPR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. CD-MPR (cation-dependent mannose-6-phosphate receptor) is an oligomeric transmembrane protein that plays a critical role in the intracellular delivery of phosphorylated lysosomal enzymes from the trans-Golgi network (TGN). Intracellular trafficking of CD-MPR is mediated by sorting signals in its 67 amino acid cytoplasmic tail, which prevent it from entering the lysosome, where it would be degraded. CD-MPR is predominantly expressed in mouse testicular germ cells and shows differentiated expression during maturation of rat spermatozoa. Increased expression of CD-MPR in Alzheimer's disease and the location of the CD-MPR gene next to a region on chromosome 12 which is possibly linked to the disease indicate that CD-MPR may play a role in Alzheimer's disease.