Companies / Santa Cruz Biotechnology / Gα i-3 (H-7) FITC
Santa Cruz Biotechnology

Gα i-3 (H-7) FITC | Santa Cruz Biotechnology

mouse monoclonal IgG3; Gα i-3 Antibody (H-7) is an IgG3 κ mouse monoclonal Gα i-3 antibody (also designated Gα i-3 antibody or G protein subunit GNAI3 antibody) that detects Gα i-1 and Gα i-3 of mouse, rat and human origin by WB, IP, IF and ELISA. Gα i-3 Antibody (H-7) is available as both conjugated and non-conjugated anti-Gα i-3 antibody forms. Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. Each of a very broad range of receptors specifically detects an extracellular stimulus (a photon, pheromone, odorant, hormone or neurotransmitter) while the effectors (i.e., adenylyl cyclase), which act to generate one or more intracellular messengers, are less numerous. In mammals, G protein α, β and γ polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four distinct classes of Gα subunits have been identified; these include Gs, Gi, Gq and Gα 12/13. The Gi class comprises all the known a subunits that are susceptible to pertussis toxin modifications, including Gα i-1, Gα i-2, Gα i-3, Gα o, Gα t1, Gα t2, Gα z and Gα gust. Of these, the three Ga i subtypes function to open atrial potassium channels.

Reviews


No reviews yet

ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.