mouse monoclonal IgG1; Cyr61 Antibody (A-10) is an IgG1 κ mouse monoclonal Cyr61 antibody (also designated CCN1 antibody, or CYR61 antibody) that detects the Cyr61 protein of human origin by WB, IP, IF, IHC(P) and ELISA. Cyr61 Antibody (A-10) is available as both the non-conjugated anti-Cyr61 antibody form, as well as multiple conjugated forms of anti-Cyr61 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cyr61 is a secreted heparin binding protein, encoded by a growth factor-inducible immediate-early gene, that associates with the extracellular matrix and connective tissue. Cyr61 is a member of a distinct family of angiogenic and vasculogenic regulators designated CCN proteins, which includes connective tissue growth factor (CTGF) and the mouse Cyr61 homolog, Fisp12. As an angiogenic inducer, Cyr61 binds to the cell surface receptor Integrin aV/b3, where it then stimulates cell adhesion and migration and promotes DNA synthesis of human vascular endothelial cells. Expression of Cyr61 is elevated during vessel growth, wound healing and chondrocyte differentiation. Cyr61 is also detected in a wide variety of tumors as it induces tumor growth and functions as a marker of tumor progression.