mouse monoclonal IgG1; MULK Antibody (F-3) is an IgG1 κ mouse monoclonal MULK antibody (also designated MULK antibody) that detects the MULK protein of mouse, rat and human origin by WB, IP, IF and ELISA. MULK Antibody (F-3) is available as both the non-conjugated anti-MULK antibody form, as well as multiple conjugated forms of anti-MULK antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. MULK (multi-substrate lipid kinase), also known as AGK (acylglycerol kinase), is a 422 amino acid protein that localizes to the mitochondrial membrane and is highly expressed in muscle, heart, kidney and brain. Containing one DAGKc domain, MULK acts as a lipid kinase that phosphorylates monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. When overexpressed, MULK increases the production and secretion of LPA, thereby transactivating EGFR and ERK signaling pathways, which in turn lead to increased cell growth. Due to its involvement of LPA overproduction, MULK is implicated in the initiation and progression of prostate cancer. MULK utilizes magnesium as a cofactor and exists as two alternatively spliced isoforms. MULK is encoded by a gene mapping to 7q34.