mouse monoclonal IgG2a; ACTR-I Antibody (C-5) is an IgG2a κ mouse monoclonal ACTR-I antibody (also designated ACTR-I antibody) that detects the ACTR-I protein of mouse, rat and human origin by WB, IP, IF and ELISA. ACTR-I Antibody (C-5) is available as both the non-conjugated anti-ACTR-I antibody form, as well as multiple conjugated forms of anti-ACTR-I antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the transforming growth factor b superfamily bind to a pair of transmembrane proteins, known as receptor types I and II, which contain serine/threonine kinases and associate to form a signaling complex. Activin has been shown to bind a heteromeric noncovalent complex, which consists of a type I receptor, ACTR-IA (also designated ACVRI and ALK-2) or ACTR-IB (also designated ALK-4 and SKR2), and a type II receptor, ACTR-IIA (also designated ACVR2A) or ACTR-IIB (also designated ACVR2B). Both receptor types are highly expressed in brain. The activin receptor family members are thought to mediate distinct effects on gene expression, cell differentiation, and morpho- genesis in a dose dependent fashion.