mouse monoclonal IgG1; hepatic OAT Antibody (D-10) is an IgG1 κ mouse monoclonal hepatic OAT antibody (also designated hepatic OAT antibody) that detects the hepatic OAT protein of mouse, rat and human origin by WB, IP, IF and ELISA. hepatic OAT Antibody (D-10) is available as both the non-conjugated anti-hepatic OAT antibody form, as well as multiple conjugated forms of anti-hepatic OAT antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. OAT (ornithine aminotransferase (mitochondrial), ornithine-oxo-acid aminotransferase) is a 439 amino acid protein encoded by the human gene OAT. OAT belongs to the class III pyridoxal-phosphate-dependent aminotransferase family and is usually found as a homotetramer in the mitochondrion matrix. OAT catalyzes the major catalytic reaction for ornithine. Ornithinemia, presumably due to deficiency of ornithine ketoacid aminotransferase (OAT) has been found in patients with gyrate atrophy of the choroid and retina. The clinical history of gyrate atrophy is usually night blindness that begins in late childhood, accompanied by sharply demarcated circular areas of chorioretinal atrophy. During the second and third decades the areas of atrophy enlarge. The hepatic cleavage product, hepatic OAT, is formed by cleaving a 25 amino acid transit peptide from the N-terminus of the OAT precursor. The renal form is produced by cleaving a 35 amino acid transit peptide from the N-terminus.