mouse monoclonal IgG1; proenkephalin B Antibody (D-6) is an IgG1 κ mouse monoclonal proenkephalin B antibody (also designated proenkephalin B antibody) that detects the proenkephalin B protein of mouse and rat origin by WB, IP, IF and ELISA. proenkephalin B Antibody (D-6) is available as both the non-conjugated anti-proenkephalin B antibody form, as well as multiple conjugated forms of anti-proenkephalin B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The proenkephalin precursor proteins are secreted proteins belonging to the opioid neuropeptide precursor family. The proenkephalin proteins are proteolytically processed to form active secreted opioid peptides, which function as ligands for the κ-type of opioid receptor. The proenkephalin A precursor contains Synenkephalin, Leu-enkephalin and Met-enkephalin processed active peptides, while the proenkephalin B precursor contains β-neoendorphin, Dynorphin, Leumorphin, Leu-enkephalin and rimorphin processed active peptides. β-endorphin and Met-enkephalin are endogenous opiates, while ACTH is crucial for adrenal gland stimulation to release cortisol. MSH increases melanin production in melanocytes, which leads to an increase in skin pigmentation. Leumorphin may be important in apoptosis prevention by being involved in the MAP kinase and PI 3-kinase pathways.