mouse monoclonal IgG1; TMCC3 Antibody (D-6) is an IgG1 κ mouse monoclonal TMCC3 antibody (also designated TMCC3 antibody) that detects the TMCC3 protein of mouse, rat and human origin by WB, IP, IF and ELISA. TMCC3 Antibody (D-6) is available as both the non-conjugated anti-TMCC3 antibody form, as well as multiple conjugated forms of anti-TMCC3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. TMCC3 (transmembrane and coiled-coil domains protein 3) is a 477 amino acid multi-pass membrane protein that belongs to the TEX28 family. The gene that encodes TMCC3 contains approximately 83,429 bases and maps to human chromosome 12q22. Encoding over 1,100 genes within 132 million bases, chromosome 12 makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12, including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Noonan syndrome, which includes heart and facial developmental defects among the primary symptoms, is caused by a mutant form of PTPN11 gene product, SH-PTP2. Chromosome 12 is also home to a homeobox gene cluster, which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster, encoding C-type lectin proteins that mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms that vary in severity depending on the extent of mosaicism. It is most severe in cases of complete trisomy.