mouse monoclonal IgM; IPO-38 Antibody (IPO-38) is an IgM κ mouse monoclonal IPO-38 antibody (also designated IPO-38 antibody) that detects the IPO-38 protein of mouse, rat and human origin by IP, IF and FCM. IPO-38 Antibody (IPO-38) is available as both the non-conjugated anti-IPO-38 antibody form, as well as multiple conjugated forms of anti-IPO-38 antibody, including PE, FITC. IPO-38, also known as non-lineage 116 (N-L116), is an antigen present in the nuclei of proliferating cells. It can be detected in different forms of leukemias as well as Hodgkin's disease and non-Hodgkin's lymphomas, breast and colorectal carcinomas and PHA-stimulated lymphocytes. Upregulated in gastric cancer, IPO-38 is also a promising biomarker for predicting the prognosis of gastric cancer. In addition, sequence analysis of the IPO-38 antigen immunoprecipiated from a gastric cancer cell line, suggests that IPO-38 may be a modified form of the Histone H2B antigen. The presence of nuclear IPO-38 antigen has been identified in different human and murine lymphoid and non-lymphoid cell lines, but not in mononuclear cells and granulocytes of healthy donors. IPO-38 is thus a proliferation marker that may be useful when monitoring tumor progression.