mouse monoclonal IgG1; GSK3 alpha Antibody (H-12) is an IgG1 κ mouse monoclonal GSK3alpha antibody (glycogen synthase kinase 3 antibody, GSK-3α antibody or GSK3 antibody) that detects the GSK3A protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. GSK-3α Antibody (H-12) is available as both the non-conjugated anti-GSK-3 alpha antibody form, as well as multiple conjugated forms of anti-GSK-3 alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glycogen synthase kinase 3, or GSK-3, is a serine/threonine, proline-directed kinase involved in a diverse array of signaling pathways, including glycogen synthesis and cellular adhesion, and has been implicated in Alzheimer's disease. Two forms of GSK-3, designated GSK-3α and GSK-3β, have been identified and differ in their subcellular localization. Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyper-phosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimer's disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK-3. This presents the possibility that miscues in GSK-3 signaling contribute to the onset of Alzheimer's disease.