mouse monoclonal IgG1; Tyk 2 Antibody (C-8) is an IgG1 κ mouse monoclonal Tyk 2 antibody (also designated TYK2 antibody, Janus kinase (JAK) family protein tyrosine kinase antibody, JTK1 antibody, cytoplasmic type I / type II cytokine receptor interacting protein antibody, type I / type III interferon signaling pathway component antibody, or immune response / antiviral activity related protein antibody) that detects the Tyk 2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Tyk 2 Antibody (C-8) is available as both the non-conjugated anti-Tyk 2 antibody form, as well as multiple conjugated forms of anti-Tyk 2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Tyk 2 belongs to the family of non-receptor janus tyrosine kinases, which regulate a spectrum of cellular functions occurring downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, recruit STAT transcription factors to the cytokine receptor where Tyk 2 is associated. Tyk 2 then phosphorylates proximal STAT factors, which subsequently dimerize, translocate to the nucleus, and bind to cis elements upstream of target gene promoters to regulating transcription. The canonical JAK-STAT pathway is integral to maintaining a normal immune system by stimulating proliferation, differentiation, survival, and host resistance to pathogens. Cytokine induced pro-inflammatory responses are attractive targets for anti-inflammatory therapies, specifically at the level of Jak-STAT signaling.