mouse monoclonal IgG1; Bcl10 Antibody (331.3) is an IgG1 κ mouse monoclonal Bcl10 antibody (also designated BCL10 immune signaling adaptor antibody) that detects the Bcl10 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Bcl10 Antibody (331.3) is available as both the non-conjugated anti-Bcl10 antibody form, as well as multiple conjugated forms of anti-Bcl10 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFκB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.