mouse monoclonal IgG1; cyclin A2 Antibody (46B11) is an IgG1 κ mouse monoclonal cyclin A2 antibody (also designated CCNA2 antibody) that detects the cyclin A2 protein of Xenopus laevis origin by . cyclin A2 Antibody (46B11) is available as both the non-conjugated anti-cyclin A2 antibody form, as well as multiple conjugated forms of anti-cyclin A2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cyclin A2 is a member of the highly conserved cyclin family. Cyclins regulate CDK kinases and different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. Cyclin A2 is expressed in all tissues tested, in contrast to cyclin A1, which is present only in germ cells. The Cyclin A2 protein binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. Cyclin A2 also functions in the transition to DNA replication and synthesis phases of the cell cycle and is quickly destroyed as the cell moves into mitosis.