mouse monoclonal IgG1; CGRP Antibody (4901) is an IgG1 κ mouse monoclonal CGRP antibody (also designated CALC antibody, CALCA antibody, CALCB antibody, Calcitonin Related Polypeptide antibody, CGRP1 antibody, CGRP2 antibody, Calcitonin Gene-Related Peptide II antibody, Calcitonin Gene-Related Peptide 2 antibody, Beta-Type CGRP antibody, Alpha-Type CGRP antibody, Calcitonin 2 antibody, or Katacalcin antibody) that detects the CGRP protein of m, r, h, canine origin by WB, IP, IF and ELISA. CGRP Antibody (4901) is available as both the non-conjugated anti-CGRP antibody form, as well as multiple conjugated forms of anti-CGRP antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide known as Calcitonin gene-related peptide 1, also designated CGRP1 or α-CGRP. CGRP1 is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP1 is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or β-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.