mouse monoclonal IgG1; HHV-8 K8.1A/B Antibody (4A4) is an IgG1 κ mouse monoclonal HHV-8 K8.1A/B antibody that detects HHV-8 K8.1A and B of viral origin by WB, IP and IF. HHV-8 K8.1A/B Antibody (4A4) is available as the non-conjugated anti-HHV-8 K8.1A/B antibody form, as well as multiple conjugated forms of anti-HHV-8 K8.1A/B antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. HHV-8, also designated Kaposi's sarcoma-associated herpesvirus, is associated with multicentric Castleman's disease and primary effusion lymphoma, a rare type of non-Hodgkin lymphoma affecting the body cavities. The HHV-8 K8.1 gene encodes for two immunogenic/lytic glycoproteins that are generated by a splicing event: K8.1A and K8.1B. K8.1A is the predominant form associated with the virion envelope and is comprised of 228 residues. This protein consists of a cleavable signal sequence, a transmembrane domain, O-glycosylation sites and four N-glycosylation sites. Evidence suggests that K8.1A interacts with heparan sulfate (HS) molecules on the surface of target cells and could mediate HHV-8 interaction with HS. The K8.1B glycoprotein has 167 residues, is similar in sequence to K8.1A but it contains a 61 residue in frame deletion. In addition, K8.1B has only three N-glycosylation sites and lacks O-glycosylation sites.