mouse monoclonal IgG1; Cytokeratin 3/2p Antibody (AE5) is an IgG1 κ mouse monoclonal Cytokeratin 3/2p antibody (also designated KRT3 antibody, Keratin 3 antibody, KRT76 antibody, Keratin 76 antibody, or KRT2B antibody) that detects the Cytokeratin 3/2p protein of mouse, rat, human, rabbit and bovine origin by WB, IP, IF and IHC(P). Cytokeratin 3/2p Antibody (AE5) is available as both the non-conjugated anti-Cytokeratin 3/2p antibody form, as well as multiple conjugated forms of anti-Cytokeratin 3/2p antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The Cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. There are two types of Cytokeratins: types I and II. Type I Cytokeratins are acidic proteins, whereas type II Cytokeratins are neutral or basic proteins. Cytokeratin 3 is a type II Cytokeratin expressed in the corneal epithelium along with Cytokeratin 12. Dominant-negative mutations in the Cytokeratin 3 and Cytokeratin 12 genes cause Meesmann corneal dystrophy (MCD), an autosomal dominant disease that is characterized by weakness of the anterior corneal epithelium. Cytokeratin 2p (also designated Keratin 76) is a type II Cytokeratin expressed in palate epithelium. Cytokeratin 2p and Cytokeratin 3 proteins share significant sequence identity at the amino acid level.