mouse monoclonal IgG1; p-c-Jun Antibody (KM-1) is an IgG1 κ mouse monoclonal p-c-Jun antibody that detects c-Jun p39 phosphorylated on Serine 63 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. p-c-Jun Antibody (KM-1) is available as the non-conjugated anti-p-c-Jun antibody form, as well as multiple conjugated forms of anti-p-c-Jun antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1 (3,4), originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is deactivated upon phosphorylation induced by the cAMP-dependent protein kinase A (PKA).