mouse monoclonal IgG1; PML Antibody (PG-M3) is an IgG1 κ mouse monoclonal PML antibody that detects all isoforms of PML of human origin by WB, IP, IF and IHC(P). PML Antibody (PG-M3) is available as the non-conjugated anti-PML antibody form, as well as multiple conjugated forms of anti-PML antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The PML protein is a zinc finger transcription factor expressed as three major transcription products due to alternative splicing. The gene encoding human PML maps to chromosome 15q22. The t(15;17) (q22;q11.2-q12) chromosomal translocation of the retinoic acid receptor α (RARα) gene occurs in virtually all cases of acute promyelocytic leukemia and results in the expression of a PML/RARα chimeric protein. Myeloid precursor cells expressing the PML/RARα chimera fail to differentiate and exhibit an increased growth rate consequent to diminished apoptosis. PML/RARα transforms myeloid precursors by recruiting the nuclear co-repressor (N-CoR)-histone deacetylase complex that is essential to retinoic acid-dependent myeloid differentiation. PML/RARα also recruits DNA methyltransferases in order to induce gene hypermethylation and silencing, which ultimately facilitates leukemogenesis.