The system provides analytical performance similar to the 8- channel Octet® R8 system, but with higher levels of throughput, speed, and flexibility. The high detection sensitivity and impressive throughput of Octet® RH16 system has made it a favorite for small molecule library screening and analysis of large cross-competition binding matrices. Kinetic analysis including association and dissociation of biomolecules can be performed on up to 384 samples in one 384-well microplate. Fully automated workflows can be realized due to integrated robotic solutions, extending the unattended run time of the system. Target ligands can be batch immobilized onto biosensors and returned to the biosensor tray for re-use in future experiments, thus extending the number of uses for each biosensor, preserving valuable ligand, and maximizing flexibility in experimental design.  Key benefits: Sensitivity - Detection of low molecular weight molecules (≥ 150 Da) High throughput - 16-well simultaneous sampling in 384-well and 96-well formats Flexibility - Two plate locations maximize throughput and improve workflow Unattended operation - Automation friendliness allows multiple-plate assays in one run  User-friendliness - Advanced software offers greater versatility in experimental design and data analysis