Labroots and the Drug Discovery planning committee are pleased to announce its 3rd annual event in the Drug Discovery & Development Virtual Event Series....
Microphysiological systems (MPS), also known as organ-on-chips, are small scale in vitro cell cultures which mimic facets of tissue or organ level function. MPS frequently utilise primary hu...
The liver plays a critical role in the metabolism and clearance of more than 70% of marketed drugs. Furthermore, toxicity to the liver is a major reason for preclinical and clinical drug fai...
“The poor translatability of early-stage preclinical models is a major setback in oncology drug development. Immortalized cell lines, that are extensively used in drug screens, undergo...
Misfolded and accumulated neurodegenerative disease associated proteins (NDAPs, such as tau and alpha-synuclein) represent the major pathological hallmark in Alzheimer’s and Parkinson&...
Open Science has changed research by making data accessible and shareable, contributing to replicability to accelerate and disseminate knowledge. However, for rodent cognitive studies the av...
Chaperone networks are dysregulated with aging, but whether compromised Hsp70/Hsp90 chaperone function disturbs neuronal resilience is unknown. Stress‐inducible phosphoprotein 1 (STI1; STIP1...
Biomarkers are critical tools for all stages of cancer research, from drug development through clinical applications. Cancer is fundamentally a disease of unregulated cell growth and circumv...
Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in developed countries, and it affects over 25% of the population worldwide. Within the next five y...
Accurate DNA replication is essential to transmit the genetic information from one generation to another. However, replication is frequently challenged by barriers that originate from exogen...
The use of primary cells in vitro is compromised by the limited quantity of cells that can be isolated from one donor, a lack of or very restricted proliferation capacity (e.g. hepatocytes)...
The OrganoPlate is a microtiterplate based Organ-on-a-Chip platform for high throughput drug safety and efficacy screening. It contains up to 96 cell culture chambers that allow co-culture o...
The study of biological function in intact organisms and the development of targeted cellular therapeutics necessitate methods to image and control cellular function in vivo. Technologies su...
Striatal neuromodulation through G-protein-coupled receptors (GPCRs) regulates complex voluntary motor actions, involving decision-making, learning, and action selection. The dorsal striatum...
In Andalman et al, 2018, we explored the activity of over 10,000 neurons across more than 15 regions imaged simultaneously in larval zebrafish in a novel behavioral challenge paradigm. Compl...
DATE: December 18, 2019TIME: 10:00am PSTDavid is the Product Marketing Manager for Biosafety Cabinets at Labconco Corporation (Kansas City, MO). For several years, David has been involv...
DATE: December 17, 2019TIME: 9:00am PST, 12:00pm EST Purpose: Liver x receptors (LXRs) are hypothesized to serve as a link between lipid metabolism and inflammation by prom...
DATE: December 17, 2019 TIME: 2:00pm SGT From WHO 2017 Hepatitis report, an estimated 290 million (89%) of the 325 million people living with viral hepatitis B and C are unaware that they ar...
DATE: December 12, 2019TIME: 11:00am PST Primary immunodeficiency disorders continue to have delayed diagnoses and are commonly under diagnosed. Differentiating betw...
DATE: December 11, 2019 TIME: 8:00am PST, 11:00am EST, 4:00pm GMT The Zimmerwald Laser and Astrometric Telescope (ZIMLAT) is the most versatile instrument of the Swiss Optical Ground Stati...
DATE: December 11, 2019TIME: 7:00am PST, 10:00am EST An important part of the biopharma industry, Plasmid DNA is used as a gene-delivery vehicle for DNA vaccination and as a key...
DATE: December 10, 2019TIME: 8:00am PST, 11:00am EST In this presentation, we demonstrate the performance of a new range of Expi293 components, including engineered Expi293 cell...
DATE: December 11, 2019 TIME: 7:00am PST, 10:00am EST Rapid growth in the cell and gene therapy industry has generated an urgent need for robust analytics around characterization of both vec...
DATE: December 5, 2019TIME: 9:00am PST, 12:00pm EST Characterization of the spatial distribution and abundance of proteins and mRNAs with morphological context within tissues e...
DATE: December 5, 2019TIME: 5:00am PST, 8:00am EST The diagnosis of an active infection by the hepatitis B virus (HBV) relies on testing for the HBV surface antigen (HBsAg). Ov...
DATE: December 4, 2019 TIME: 9:00am PST, 12:00pm EST Targeted protein degradation is a novel chemical modality centered on using pharmacological agents to immediately and select...
DATE: December 4, 2019TIME: 7:00am PST, 10:00am EST, 4:00pm CET Do you know how it feels when you just quickly want to redo an experiment that your colleague did, or an experim...
DATE: December 3, 2019 TIME: 11:00am PST This talk will cover Candida auris infection, colonization, and spread through health care systems from a clinical case perspective. We will discuss...