Clinical methods describe the techniques and analyses used to collect, process, and analyze clinical data. Clinical methods are used to reach a conclusion about a patient in a medical situation. There are various goals that can be achieved by following clinical methods, including diagnosing a disease, planning a treatment regimen, or monitoring the efficacy of a treatment
The zebrafish, Danio rerio, is an ideal model organism to address a broad array of biomedical questions, and is now widely employed to answer questions about aging, behavior, cancer, growth,...
We all have to provide training; if our program is big or small, a germ-free mouse colony or field studies in Africa, centralized or not. Animal research programs, as varied as they are, have...
A problem facing the rapid growth of zebrafish as a model for human disease is a lack of qualified personnel that understand the benefits and limitations of fish culture. As this model gains...
The popularity reached by the genetic manipulation of laboratory animals to create new models for studying human diseases, produced in turn, that the techniques for assisted reproduction cons...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
Modern biomedical research greatly benefits from sophisticated techniques which can detect even the most subtle alterations between different individuals or groups. This has raised the bar fo...
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
GOAL:"A simple and reliable method for mouse intubation" is designed as an instructional tutorial with learning objectives that are twofold. First is becoming familiar with the procedure an...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Cancer metastases develop when tumor cells known as circulating tumor cells (CTCs) are shed from a tumor, circulate through the blood stream and colonize a distant tissue. The number of CTCs...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
Whenever there is cell death, apoptotic cell free DNA fragments appear in the circulation of the host. These fragments, typically 145-160 base pairs in size, represent a minute fraction of to...
RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
Non Small Cell Lung Cancer (NSCLC) is one of the most significant causes of cancer-related mortality worldwide. In about 6-7% of NSCLC, rearrangements involving the Anaplastic Lymphoma Kinase...
The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well a...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
The role of the human genome in normal and patho-biology is crucial. Applied in cancer care and in a variety of unknown disorder settings, it can provide key insights and crucial diagnostic/p...
MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
The zebrafish, Danio rerio, is an ideal model organism to address a broad array of biomedical questions, and is now widely employed to answer questions about aging, behavior, cancer, growth,...
We all have to provide training; if our program is big or small, a germ-free mouse colony or field studies in Africa, centralized or not. Animal research programs, as varied as they are, have...
A problem facing the rapid growth of zebrafish as a model for human disease is a lack of qualified personnel that understand the benefits and limitations of fish culture. As this model gains...
The popularity reached by the genetic manipulation of laboratory animals to create new models for studying human diseases, produced in turn, that the techniques for assisted reproduction cons...
The title of this presentation could have been Training within laboratory animal science - where we are and where we should be. While training has been the domain of facility managers for ma...
Modern biomedical research greatly benefits from sophisticated techniques which can detect even the most subtle alterations between different individuals or groups. This has raised the bar fo...
Training in your own institution or corporation can be challenging in trying to meet the goals of the program and the needs of the researchers. If you are challenged with training visiting in...
All personnel involved in an animal care and use program are expected to have an appropriate level of education, training and/or qualifications to perform their duties as defined through laws...
Almost all discussion to date on the ethics of animal use in research has revolved around the balance of harms (to the animals) versus benefits (to us) associated with conducting the researc...
Non-surgical transfer techniques for mouse embryos and sperm provide animal welfare benefits for assisted reproduction of mice. While surgical embryo transfer (ET) is an effective method for...
An anesthesia system designed to accommodate the physiological characteristics of small animals, including rats and mice, has the potential to provide great practical value to the life scien...
GOAL:"A simple and reliable method for mouse intubation" is designed as an instructional tutorial with learning objectives that are twofold. First is becoming familiar with the procedure an...
The discovery of proteinaceous disease biomarkers and their clinical validation is critically important for the enablement of molecular diagnostics and ultimately, precision medicine. In spit...
Cancer metastases develop when tumor cells known as circulating tumor cells (CTCs) are shed from a tumor, circulate through the blood stream and colonize a distant tissue. The number of CTCs...
Many drugs currently used for anti-cancer therapy demonstrate significant inter-individual variability that cannot be normalized using body weight or body surface area. There is an increasing...
Whenever there is cell death, apoptotic cell free DNA fragments appear in the circulation of the host. These fragments, typically 145-160 base pairs in size, represent a minute fraction of to...
RNA-Seq allows the simultaneous observation of gene expression levels, mutations in the coding sequences, splice variants and gene fusions, which are especially important in cancer studies. A...
Non Small Cell Lung Cancer (NSCLC) is one of the most significant causes of cancer-related mortality worldwide. In about 6-7% of NSCLC, rearrangements involving the Anaplastic Lymphoma Kinase...
The eukaryotic translation initiation factor eIF4E is a potent oncogene estimated to be elevated in about 30% of human cancers including cancers of the breast, prostate, lung, colon as well a...
The effective implementation of personalised cancer therapeutic regimens depends on the successful identification and translation of informative biomarkers to aid clinical decision making. Th...
Survival rates for early stage non-small cell lung cancer (NSCLC) remain unacceptably low compared to other common solid tumors. This mortality reflects a weakness in conventional staging, a...
The use of ultrahigh throughput diagnostic tests that determine genetic sequence variation to guide patient care is rapidly expanding, fueled by the enormous growth in sequencing platform dev...
The role of the human genome in normal and patho-biology is crucial. Applied in cancer care and in a variety of unknown disorder settings, it can provide key insights and crucial diagnostic/p...
MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half o...
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