Dominant regulation of gene expression by microRNAs

MicroRNAs are short non-coding cellular regulators of gene expression. Each microRNA controls the expression of a large set of genes, and microRNAs collectively, may regulate more than half of human genes. In the laboratory, our team focuses on understanding the function of microRNAs in health and during disease. We map their expression in developing cancer cells and in various brain disorders. We predict direct gene targets of these microRNAs sets and then pinpoint the cellular pathways affected. I will present our recent findings in the field and discuss its potential implications for prognosis and diagnosis. Overall our team pursues research that aims to deepen our understanding on the development of diseases in order to generate a significant impact through translating ideas into clinical reality.