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Protein Binding
Protein Binding: Protein binding can enhance or detract from a drug's performance. As a general rule, agents that are minimally protein bound penetrate tissue better than those that are highly bound, but they are excreted much faster. Among drugs that are less than 80-85 percent protein bound, differences appear to be of slight clinical importance. Agents that are highly protein bound may, however, differ markedly from those that are minimally bound in terms of tissue penetration and half-life. Drugs may bind to a wide variety of plasma proteins, including albumin. If the percentage of protein-bound drug is greater when measured in human blood than in a simple albumin solution, the clinician should suspect that the agent may be bound in vivo to one of these "minority" plasma proteins. The concentration of several plasma proteins can be altered by many factors, including stress, surgery, liver or kidney dysfunction, and pregnancy. In such circumstances, free drug concentrations are a more accurate index of clinical effect than are total concentrations. Formulary committees must grasp the clinical significance of qualitative and quantitative differences in protein binding when evaluating competing agents.
FEB 23, 2022 | 6:00 AM
Cancer still accounts for nearly 1 in every 4 deaths worldwide. New immunotherapies have the power to induce durable responses in patients with fatal cancers, but only a small percentage of...
DEC 07, 2021 | 9:00 AM
Date: December 7, 2021 Time: 9:00am (PST), 12:00pm (EST) The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than...
NOV 08, 2021 | 8:00 AM
Date: November 8, 2021 Time: 8:00am (PDT), 11:00am (EDT) Explore the adaptability of your KingFisher instrument. Discover all the ways your Thermo Scientific™ KingFisher™ system...
OCT 20, 2021 | 9:00 AM
Date: October 20, 2021 Time: 9:00am PDT Cryo-electron microscopy (cryo-EM) is rapidly evolving to be the primary tool for structure determination of membrane proteins. However, generation of...
OCT 14, 2021 | 9:00 AM
Date: October 14, 2021 Time: 9:00am (PDT), 12:00pm (EDT), 5:00pm GMT Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring spe...
OCT 14, 2021 | 7:00 AM
Date: October 14, 2021 Time: 7:00am (PDT), 10:00am (EDT) Heterologous protein expression in model organisms has many applications, including protein engineering, production of industrial enz...
OCT 13, 2021 | 7:00 AM
Date: October 13, 2021 Time: 7:00am (PDT), 10:00am (EDT) Western blot analysis is a method widely used in the lab today because of its versatility in detecting and measuring specific target...
OCT 12, 2021 | 5:00 PM
Date: October 12, 2021 Time: 5:00pm (PDT), 8:00pm (EDT) 222 Learning Objectives 222 222 222 Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved...
SEP 14, 2021 | 7:00 AM
Date: September 14, 2021 Time: 7am PDT, 10am EDT, 4pm CEST A conventional thermal cycler has long been a commodity product in the lab and end-point PCR techniques can be completed almost wit...
AUG 25, 2021 | 9:00 AM
Date: August 25, 2021 Time: 9:00am PDT During this interactive webinar you can ask questions, get answers, and engage with Taiana De Oliveira from AstraZeneca, Steven Litster, Brian Skjerven...
AUG 25, 2021 | 7:30 AM
The misfolding of intrinsically disordered proteins (IDPs) such as tau and α-synuclein (αSyn) has been associated with the on-set and progression of Alzheimer’s (AD) and Pa...
JUN 15, 2021 | 10:00 AM
Date: June 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time binding affinity and kinetics of...
JUN 09, 2021 | 7:00 AM
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
MAY 13, 2021 | 8:00 AM
Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
MAY 11, 2021 | 10:00 AM
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 29, 2021 | 9:00 AM
Date: April 29, 2021 Time: 9:00am PST Cryo-electron microscopy (cryo-EM) reached single-atom resolution for 3D structure determination of biological macromolecules. Cryo-EM has been determin...
APR 20, 2021 | 12:00 AM
Nanopore sequencing has enormous potential in epigenetic applications; unlike traditional sequencing-by-synthesis technologies, it can distinguish covalently modified nucleotides directly th...
APR 07, 2021 | 7:00 AM
DATE: April 7, 2021 TIME: 7:00am PDT Abstract: Learning objectives: Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provider of continu...
APR 06, 2021 | 10:00 AM
DATE: April 6, 2021 TIME: 10:00am PDT Accurate and efficient data analysis of protein targets is an integral part of the gel and western blot imaging workflow. The Invitrogen iBright Analysi...
APR 01, 2021 | 8:00 AM
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
MAR 31, 2021 | 9:00 AM
Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
MAR 31, 2021 | 8:00 AM
Date: March 31, 2021 Time: 08:00am PST CytoFLEX SRT has enabled researcher lead self-service sorting. The need for a cell sorting expert to setup and maintain the sorter status is now necess...
FEB 24, 2021 | 1:30 PM
G protein-coupled receptors (GPCRs) are among the most intensively studied drug targets, and account for about ~34% of all drugs approved by the FDA. Examples of drugs targeting GPCRs includ...
JUN 15, 2021 | 10:00 AM
Date: June 15, 2021 Time: 10:00am (PDT), 1:00pm (EDT) SPRm (Surface Plasmon Resonance Microscopy) is a novel technology that enables label-free and real-time binding affinity and kinetics of...
JUN 09, 2021 | 7:00 AM
Date: June 9, 2021 Time: 09 June 2021, 7am PDT, 10am EDT, 4pm CEST cells with dramatic implications on the validity of past cell culture related research. The fact that at least 509 cell lin...
MAY 13, 2021 | 8:00 AM
Date: May 13, 2021 Time: 8:00am (PDT), 11:00am (EDT) Antibodies are the most rapidly growing form of therapeutic. High-throughput methods of characterization are essential as companies and r...
MAY 11, 2021 | 10:00 AM
Date: May 11, 2021 Time: 10:00zm PDT Your samples are some of the most valuable assets in the laboratory. After spending countless hours on extraction and preparation, your conclusions could...
APR 29, 2021 | 9:00 AM
Date: April 29, 2021 Time: 9:00am PST Cryo-electron microscopy (cryo-EM) reached single-atom resolution for 3D structure determination of biological macromolecules. Cryo-EM has been determin...
APR 20, 2021 | 12:00 AM
Nanopore sequencing has enormous potential in epigenetic applications; unlike traditional sequencing-by-synthesis technologies, it can distinguish covalently modified nucleotides directly th...
APR 07, 2021 | 7:00 AM
DATE: April 7, 2021 TIME: 7:00am PDT Abstract: Learning objectives: Webinars will be available for unlimited on-demand viewing after live event. LabRoots is approved as a provider of continu...
APR 06, 2021 | 10:00 AM
DATE: April 6, 2021 TIME: 10:00am PDT Accurate and efficient data analysis of protein targets is an integral part of the gel and western blot imaging workflow. The Invitrogen iBright Analysi...
APR 01, 2021 | 8:00 AM
Date: April 01, 2021 Time: 8:00am (PST), 11:00am (EST) Generating therapeutic antibodies is far more challenging than obtaining antibodies that merely recognize their targets. Engineering po...
MAR 31, 2021 | 9:00 AM
Date: March 31, 2021 Time: 9:00am (PDT), 12:00pm (EDT) Knockdown studies are prevalent and powerful ways to illustrate gene function. CRISPRi delivers a new mechanism for gene knockdown, PAM...
MAR 31, 2021 | 8:00 AM
Date: March 31, 2021 Time: 08:00am PST CytoFLEX SRT has enabled researcher lead self-service sorting. The need for a cell sorting expert to setup and maintain the sorter status is now necess...
FEB 24, 2021 | 1:30 PM
G protein-coupled receptors (GPCRs) are among the most intensively studied drug targets, and account for about ~34% of all drugs approved by the FDA. Examples of drugs targeting GPCRs includ...