A study published in Scientific Reports is the first human clinical trial to examine the effects of the cannabinoid cannabigerol (CBG) on mental wellness. CBG is often referred to as "the mother of all cannabinoids" because many other cannabinoids derive from cannabigerolic acid (CBGA), which is an acidic form of CBG. Researchers from Washington State University (WSU) and the University of California, Los Angeles found that hemp-derived CBG improves mood, reduces anxiety, and eases stress.
The research team conducted a double-blind, placebo-controlled, experimental trial with 34 participants who are self-reported cannabis users. The participants completed two Zoom sessions to establish baseline ratings of their mood, anxiety, and stress levels. They then consumed either 20 mg of hemp-derived CBG or a placebo tincture provided by the research team. The participants reevaluated and rated their mood, stress, and anxiety. They noted any psychoactive effects and how the cannabinoid product made them feel at three different time points after consumption. The participants engaged in sessions a week later but took the alternate product before completing the same assessments. This methodology ensured neither party (researchers or participants) knew which product they ingested.
The study found that 20 mg of CBG significantly reduced feelings of anxiety at 20, 45, and 60 minutes after ingestion compared to a placebo. CBG also decreased stress ratings at the first time point compared to the placebo. The participants did not experience significant mood enhancement.
The study showed that CBG enhanced memory. When asked to recall lists of words, participants recalled more words after taking 20 mg of CBG than after taking a placebo.
The study indicated that CBG did not cause cognitive or motor impairments. It also did not produce other adverse effects often experienced with the psychoactive cannabis compound tetrahydrocannabinol (THC). The participants in the experimental group reported minimal psychoactive effects and few changes in minor adverse effects like dry mouth or drowsiness.
Sources: Eureka News Alert, Scientific Reports
