Fellow in Comparative Pathology at University of Pennsylvania
BIOGRAPHY
Characterization of Myeloid Cell Hyperactivation Syndrome and Survival Differences in Humanized NOG-EXL and NSG-SGM3 Mice
Speaker
Event Date & Time
Date: December 17, 2024
Time: 11:00am PT, 2:00pm ET
Abstract
Super immunodeficient mice such as the NOG-EXL and NSG-SGM3 combine severe immunodeficiency with transgenic expression of human myeloid-stimulatory cytokines. These mouse strains support an improved expansion of human myeloid cell populations following engraftment with human CD34+ hematopoietic stem cells (HSC). The application of these valuable humanized immune system (HIS) models can be complicated by adverse events that limit their use in long-term studies.
In this webinar, Dr. Elinor Willis will cover the characterization of myeloid cell hyperactivation syndrome in CD34+ HSC-humanized NSG-SGM3 and NOG-EXL mice, including significant new histopathology data in various tissues. Learn about important differences in overall survival and severity of myeloid cell hyperactivation syndrome between strains. These differences are relevant to selecting the most appropriate HIS model for longer-term studies.
View this webinar presentation to:
- Review key host strains used to develop humanized immune system mouse models that support expansion of both human lymphoid and myeloid cells
- Get insight into the type of adverse outcomes that can develop in myeloid-supportive HIS mice, including mast cell hyperplasia and lethal macrophage activation syndrome
- Explore how myeloid cell hyperactivation syndrome presents in two different host strains following HSC engraftment
- Discover how myeloid cell hyperactivation syndrome presents in different tissues
- Discover how myeloid cell hyperactivation syndrome can impact lifespan and study window in HIS mice
Webinars will be available for unlimited on-demand viewing after live event.
Labroots is approved as a provider of continuing education programs in the clinical laboratory sciences by the ASCLS P.A.C.E. ® Program. By attending this webinar, you can earn 1 Continuing Education credit once you have viewed the webinar in its entirety.
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