Clinical Development Specialist, Promega Corporation
BIOGRAPHY
June 29, 2021 10:40 AM CDT
Development of a Microsatellite Instability Assay Utilizing Novel Long Repeats
Presented at:
A Microsatellite Instability (MSI) Series
Speaker
Abstract
Dr. Samantha Lewis will discuss the value of MSI as a biomarker and techniques to measure microsatellite instability. She will then describe the development of a new PCR assay to detect MSI in solid tumors utilizing a new 8-marker panel that includes both gold standard markers and novel long mononucleotide repeats for a research-based approach to maximize sensitivity. Dr. Lewis will demonstrate the utility of this novel panel by showcasing studies using difficult and degraded samples (ccfDNA and FFPE).
Learning Objectives:
- Demonstrate how mismatch repair deficiency causes microsatellite instability
- Recognize techniques to measure microsatellite instability
- Discuss why long mononucleotide markers may offer a different perspective on MSI
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