Genomic Profiles of Asian Endemic Cancers

Malignancies caused by so-called Type I chemical and biological carcinogens provide important opportunities studying early events in cancer development, providing essential information for developing future cancer prevention strategies. In Asia, several highly lethal cancers are known to be caused by pathogens, such as stomach cancers (H. pylori), bile duct cancers (liver flukes), and certain lymphoma subtypes (Epstein-Barr Virus). For many of these conditions, treatment options are still highly limited. In this talk, I will describe how genomic analysis of infection-related Asian cancers can provide insights into cellular processes disrupted by these pathogens, and how such data can be used to identify new therapeutic targets.