Immune-competent vascularized human cerebral organoids to study brain development and disease: a multiomics approach

Grab your cup of coffee and join us for the Multiomics Coffee Break with a presentation from The Network Biology Collaborative Centre at Mount Sinai Hospital, Olink Certified Service Provider.

With Olink Certified Service Providers, you can confidently outsource your projects, ensuring top-tier data quality, faster research timelines, and seamless multi-omics integration—from project planning to data delivery.

Using next-generation proteomics technologies, organoid-based research models have the potential to revolutionize drug discovery and personalized medicine, improving our understanding of neuroimmune interactions and brain inflammation responses in human-specific models.

To understand the mechanism and regulatory pathways involved in human brain development and disease, a vascularized derived human cerebral organoids (hCO) model integrated with human pluripotent stem cell (hPSC)-derived human hematopoietic progenitor cells (hHPCs) was developed. Protein profiling of 92 immune-related biomarkers was performed in multiplex using the Proximity Extension assay to characterize and validate the functionality of microglia in response to the bacterial cell wall component Lipopolysaccharide. This data further improves our understanding of neuroimmune interactions and brain inflammation responses in human-specific models.

Join this webinar to learn:

• How protein profiling of an organoid-based model provided novel regulatory and mechanistic insights into human brain development.
• How Olink’s Proximity Extension Assay technology is advancing protein biomarker discovery and implementation in neurological research, by delivering robust performance while consuming just 1 μL of sample.
• The utility of the Olink technology in organoid research and how it integrates seamlessly with other omics data.

Register now and be a part of the multiomics revolution! 

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